Possible reasons
Interruptions to routine immunization
The coverage of the third dose of the diphtheria-tetanus-pertussis (DTP3) vaccine from 86% in 2019 to 81% in 2021, the lowest since 2008
PHSMs lead to a lack of immune stimulation in the population
As PHSMs relax, more susceptible individuals may result in pertussis levels approaching or even surpassing pre-pandemic levels
Macrolide-resistant strains of Bordetella pertussis
In 2020, a new type of macrolide-resistant pertussis bacterium containing the pxxP3 and prn2 genes emerged in Shanghai, China, and rapidly spread in the subsequent period, replacing the previous predominant strain.
Acellular pertussis vaccines
limited efficacy in against infection and transmission
National vaccine strategy
Publications and projects
(https://toolbox.ctmodelling.cn/)
Epidemiologist Toolbox
CNIDS
Background
Why do not build a dashboard for every reported infectious disease?
Dynamic surveillance
AI-driven Report
Chinese Notifiable Infectious Diseases Surveillance Report
What’s more?
provided by gmail to send information (developing)
provided by microsoft to recording subscribe and unsubscribe
Project design
Further direction
Local deploying open source model to avoid data breaches
Source: Cascella et al. J Med Syst 2024
Including more countries and regions
Source: Healthmap
Pertussis resurgence
Global situation
the UK, the US, Australia, Philippines, European Union and …
(a-b) Australia; (c-d) China; (e-f) the UK; (g-h) the US.
Unpublished result
(a-b) Australia; (c-d) China; (e-f) the UK; (g-h) the US.
Unpublished resultPossible reasons
Interruptions to routine immunization
The coverage of the third dose of the diphtheria-tetanus-pertussis (DTP3) vaccine from 86% in 2019 to 81% in 2021, the lowest since 2008
PHSMs lead to a lack of immune stimulation in the population
As PHSMs relax, more susceptible individuals may result in pertussis levels approaching or even surpassing pre-pandemic levels
Macrolide-resistant strains of Bordetella pertussis
In 2020, a new type of macrolide-resistant pertussis bacterium containing the pxxP3 and prn2 genes emerged in Shanghai, China, and rapidly spread in the subsequent period, replacing the previous predominant strain.
Acellular pertussis vaccines
limited efficacy in against infection and transmission
National vaccine strategy
More information
Unpublished result
